Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age
worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility …

The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of
COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of …

Natural products (NPs) are always a promising source of novel drugs for tackling unsolved
diseases [1–3]. Natural molecules have addressed the rational design of many synthetic …

Cancer is a leading cause of human death, and there is a need to identify efficient and novel
chemical scaffolds which could provide flexibility to cancer chemotherapeutics. This work …

Mutations in homodimeric isocitrate dehydrogenase (IDH) enzymes at specific arginine
residues result in the abnormal activity to overproduce D-2 hydroxyglutarate (D-2HG), which …

Polyaza-heterocycles show a plethora of biological properties and represent a significant
percentage of clinically used drugs. However, the imizado [1, 2-a] pyrimidine ring system …

Breast cancer (BRCA) remains the most prevalent cancer worldwide and the tumor
microenvironment (TME) has been discovered to exert a wide influence on the overall …

With the deepening of people's understanding of lung cancer, the research of lung cancer
immunotherapy has gradually become the focus of attention. As we all know, the treatment …

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant
promise to provide valuable insights to the field of mitochondrial research and aging biology …

Ensuring the safety and efficacy of chemical compounds is crucial in small-molecule drug
development. In the later stages of drug development, toxic compounds pose a significant …