The development of single-cell multimodal assays provides a powerful tool for investigating
multiple dimensions of cellular heterogeneity, enabling new insights into development …

Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Different plant species within the grasses were parallel targets of domestication, giving rise
to crops with distinct evolutionary histories and traits. Key traits that distinguish these species …

Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …

Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the
origins of cellular diversity and assist the annotation of new cell atlases. Yet, comparison …

Aims Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic
cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Despite extensive efforts to generate and analyze reference genomes, genetic models to
predict gene regulation and cell fate decisions are lacking for most species. Here, we …

A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …

Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …