Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

C Pifferi, R Fuentes, A Fernández-Tejada - Nature Reviews Chemistry, 2021 - nature.com
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …

mRNA vaccine against malaria tailored for liver-resident memory T cells

M Ganley, LE Holz, JJ Minnell, MN de Menezes… - Nature …, 2023 - nature.com
Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

[HTML][HTML] Emerging vaccine nanotechnology: from defense against infection to sniping cancer

C Feng, Y Li, BE Ferdows, DN Patel, J Ouyang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Looking retrospectively at the development of humanity, vaccination is an unprecedented
medical landmark that saves lives by harnessing the human immune system. During the …

Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases

JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …

Mosquirix™ RTS, S/AS01 vaccine development, immunogenicity, and efficacy

AY Nadeem, A Shehzad, SU Islam, EA Al-Suhaimi… - Vaccines, 2022 - mdpi.com
Malaria is a parasitic infection caused by bites from Plasmodium falciparum (P. falciparum)-
infected mosquitoes with a present scale of symptoms ranging from moderate fever to …

Engineering self-assembling protein nanoparticles for therapeutic delivery

A Olshefsky, C Richardson, SH Pun… - Bioconjugate …, 2022 - ACS Publications
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

The road to elimination: current state of schistosomiasis research and progress towards the end game

P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …