Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Several key growth factors, cytokines, and proto-oncogenes transduce their growth-and
differentiation-promoting signals through the mitogen-activated protein kinase or …

The three mammalian Runt homology domain transcription factors (Runx1, Runx2, Runx3)
support biological control by functioning as master regulatory genes for the differentiation of …

Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal
adhesion sites, which are specific areas on the cell membrane where cells attach to …

Nuclear components are functionally linked with the dynamic temporal and spatial
compartmentalization, sorting and integration of regulatory information to facilitate its …

The role of epigenetics in modulating gene expression in the development of organs and
tissues and in disease states is becoming increasingly evident. Epigenetics refers to the …

CD44 plays a crucial role in cell migration, inflammation, and immune responses. Alteration
in the levels of CD44 expression on monocytic cells by endotoxins and immunoregulatory …

The tight association of cytoplasmic intermediate filaments (cIFs) with the nucleus and the
isolation of crosslinkage products of vimentin with genomic DNA fragments, including …

Cyclosporine-A (CyA) and FK506 are potent immunosuppressive agents because of their
ability to suppress the production of Th1 cytokines including interleukin (IL)-12. However, the …

DNA‐dependent protein kinase (DNA‐PK), a nuclear serine/threonine kinase, is responsible
for the DNA double‐strand break repair. Cells lacking or with dysfunctional DNA‐PK are …