Atherosclerosis and inflammation: insights from the theory of general pathological processes

E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Insights into pathogenesis, nutritional and drug approach in sarcopenia: a systematic review

RH Mellen, OS Girotto, EB Marques, LF Laurindo… - Biomedicines, 2023 - mdpi.com
Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due
to aging, eating habits, physical inactivity, or even caused by another disease. Affected …

[HTML][HTML] Multimodal cell atlas of the ageing human skeletal muscle

Y Lai, I Ramírez-Pardo, J Isern, J An, E Perdiguero… - Nature, 2024 - nature.com
Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and
are critical contributors to morbidity and mortality in older people. Deciphering the molecular …

The role of the kynurenine pathway in the pathophysiology of frailty, sarcopenia, and osteoporosis

J Ballesteros, D Rivas, G Duque - Nutrients, 2023 - mdpi.com
Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly
involved in energy metabolism and DNA production. Alterations in tryptophan metabolism …

[HTML][HTML] Inflamm-ageing: how cytokines and nutrition shape the trajectory of ageing

F Coperchini, A Greco, M Teliti, L Croce… - Cytokine & Growth …, 2024 - Elsevier
Population ageing is increasing in prevalence in most developed countries. Ageing is the
decline of functional properties at the cellular, tissue, and organ level. Biochemical changes …

Mitochondrial transplantation as a possible therapeutic option for sarcopenia

I Turkel, B Ozerklig, M Yılmaz, O Ulger… - Journal of Molecular …, 2023 - Springer
With advancing age, the skeletal muscle phenotype is characterized by a progressive loss of
mass, strength, and quality. This phenomenon, known as sarcopenia, has a negative impact …

Understanding the consequences of fatty bone and fatty muscle: how the osteosarcopenic adiposity phenotype uncovers the deterioration of body composition

K Hu, E Deya Edelen, W Zhuo, A Khan, J Orbegoso… - Metabolites, 2023 - mdpi.com
Adiposity is central to aging and several chronic diseases. Adiposity encompasses not just
the excess adipose tissue but also body fat redistribution, fat infiltration, hypertrophy of …

Hesperidin ameliorates sarcopenia through the regulation of inflammaging and the AKT/mTOR/FoxO3a signaling pathway in 22–26-month-old mice

HJ Oh, H Jin, BY Lee - Cells, 2023 - mdpi.com
Faced with a globally aging society, the maintenance of health and quality of life in older
people is very important. The age-related loss of muscle mass and strength, known as …

The integral role of magnesium in muscle integrity and aging: A comprehensive review

ACR Souza, AR Vasconcelos, DD Dias, G Komoni… - Nutrients, 2023 - mdpi.com
Aging is characterized by significant physiological changes, with the degree of decline
varying significantly among individuals. The preservation of intrinsic capacity over the …

A brief narrative review of the underlying mechanisms whereby omega-3 fatty acids may influence skeletal muscle: from cell culture to human interventions

M Taheri, PD Chilibeck, SM Cornish - Nutrients, 2023 - mdpi.com
Skeletal muscle is essential for human locomotion as well as maintaining metabolic
homeostasis. Age-related reduction in skeletal muscle mass, strength, and function (ie …