Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Clinical success of immunotherapy is driving the need for new prognostic and predictive
assays to inform patient selection and stratification. This requirement can be met by a …

Interest in spatial omics is on the rise, but generation of highly multiplexed images remains
challenging, due to cost, expertise, methodical constraints, and access to technology. An …

Automatic Non-rigid Histological Image Registration (ANHIR) challenge was organized to
compare the performance of image registration algorithms on several kinds of microscopy …

The tumor-immune microenvironment (TIME) encompasses many heterogeneous cell types
that engage in extensive crosstalk among the cancer, immune, and stromal components …

Abstract Chromosome conformation capture (3C)-based techniques have revolutionized the
field of nuclear organization, partly replacing DNA FISH as the method of choice for studying …

Multimodal image registration is a vital initial step in several medical image applications for
providing complementary information from different data modalities. Since images with …

Image registration is a fundamental task in image analysis in which the transform that moves
the coordinate system of one image to another is calculated. Registration of multi-modal …

Automated sample preparation and electron microscopy enables acquisition of very large
image data sets. These technical advances are of special importance to the field of …

Image registration is a common task for many biomedical analysis applications. The present
work focuses on the benchmarking of registration methods on differently stained histological …