Examining the shared etiology of psychopathology with genome-wide association studies

TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Exploring the genetic overlap between twelve psychiatric disorders

C Romero, J Werme, PR Jansen, J Gelernter… - Nature …, 2022 - nature.com
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …

[HTML][HTML] Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology

MD Tricklebank, TW Robbins, C Simmons… - …, 2021 - Springer
Background There is urgent need for new medications for psychiatric disorders. Mental
illness is expected to become the leading cause of disability worldwide by 2030. Yet, the last …

[HTML][HTML] Parents' depression and anxiety associated with hyperactivity-inattention and emotional symptoms in children during school closure due to COVID-19 in …

M Monnier, F Moulin, M Bailhache, X Thierry… - Scientific Reports, 2023 - nature.com
Several risk factors of children's mental health issues have been identified during the
pandemic of COronaVIrus Disease first appeared in 2019 (COVID-19). This study aims to fill …

[HTML][HTML] Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank

T Chambers, V Escott-Price, S Legge, E Baker… - Molecular …, 2022 - nature.com
Interest in the cerebellum is expanding given evidence of its contributions to cognition and
emotion, and dysfunction in various psychopathologies. However, research into its genetic …

Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood …

W Zhang, JA Sweeney, L Yao, S Li, J Zeng… - …, 2020 - nature.com
Abstract Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD)
are heritable psychiatric disorders with partially overlapping genetic liability. Shared and …

[HTML][HTML] Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study

N Madeira, JV Duarte, R Martins, GN Costa… - NeuroImage: Clinical, 2020 - Elsevier
Schizophrenia is believed to be a neurodevelopmental disease with high heritability.
Differential diagnosis is often challenging, especially in early phases, namely with other …

[HTML][HTML] Alterations in the proteome of developing neocortical synaptosomes in the absence of MET signaling revealed by comparative proteomics

KL Eagleson, P Levitt - Developmental Neuroscience, 2023 - karger.com
Alterations in the expression of genes encoding proteins involved in synapse formation,
maturation, and function are a hallmark of many neurodevelopmental and psychiatric …

Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics

MR Matos, SM Ho, N Schrode, KJ Brennand - Molecular and Cellular …, 2020 - Elsevier
Neuropsychiatric disorders are highly heritable polygenic disorders arising from the complex
interplay of highly penetrant rare variants and common variants of small effect. There is a …

Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk …

Q Zhang, X Chen, S Li, T Yao, J Wu - Journal of Psychiatric Research, 2021 - Elsevier
Existing evidence suggests that the group III metabotropic glutamate receptor (mGluR) gene
variations are involved in attention-deficit/hyperactivity disorder (ADHD), but few studies …