Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

Mycobacterium tuberculosis is a highly efficient pathogen, killing millions of infected people
annually. The capacity of M. tuberculosis to survive and cause disease is strongly correlated …

Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying
molecular components are not well defined. Using an RNA interference (RNAi)-based …

As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium
(SOC) influx is important in Ca2+ signalling and many other cellular processes,,. A calcium …

Store-operated Ca2+ entry is mediated by Ca2+ release–activated Ca2+ (CRAC) channels
following Ca2+ release from intracellular stores. We performed a genome-wide RNA …

Background Topical cyclosporine A (also known as ciclosporin A)(CsA) is an anti‐
inflammatory that has been widely used to treat inflammatory ocular surface diseases. Two …

The adaptive immune response is initiated in secondary lymphoid organs by contact
between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+ T cells. However …

Bcl-2 family members are important regulators of cell survival and cell death. Researchers
have focused mainly on mitochondria, where both proapoptotic and antiapoptotic family …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

The adenosine monophosphate (AMP)–activated protein kinase (AMPK) has a crucial role
in maintaining cellular energy homeostasis. This study shows that human and mouse T …