Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …
the biomedical community to action—to uncover and develop antiviral interventions. One …
[HTML][HTML] Natural history of COVID-19 and current knowledge on treatment therapeutic options
WG Dos Santos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Despite intense research there is currently no effective vaccine available against the new
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 …
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 …
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France
Abstract Background In France, the combination hydroxychloroquine (HCQ) and
azithromycin (AZ) is used in the treatment of COVID-19. Methods We retrospectively report …
azithromycin (AZ) is used in the treatment of COVID-19. Methods We retrospectively report …
Therapeutics data commons: Machine learning datasets and tasks for drug discovery and development
Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …
innovatiaon and impact. However, advancement in this field requires formulation of …
Azithromycin in the treatment of COVID-19: a review
D Echeverría-Esnal, C Martin-Ontiyuelo… - Expert review of anti …, 2021 - Taylor & Francis
Introduction SARS-CoV-2 is a novel virus that causes coronavirus disease-19 (COVID-19).
Antiviral and immunomodulatory agents have been proposed as potential treatments …
Antiviral and immunomodulatory agents have been proposed as potential treatments …
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
TA Tummino, VV Rezelj, B Fischer, A Fischer… - Science, 2021 - science.org
Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates
P Maisonnasse, J Guedj, V Contreras, S Behillil… - Nature, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and
no antiviral drug or vaccine is yet available for the treatment of this disease,–. Several …
no antiviral drug or vaccine is yet available for the treatment of this disease,–. Several …
[HTML][HTML] Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
RECOVERY Collaborative Group - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of
its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin …
its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin …
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
Abstract The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need …