Considerable neurological evidence indicates that the prefrontal cortex mediates complex"
executive" functions including behavioral autonomy and self-control. Given that impairments …

We hypothesize the existence of an inherited predisposition for a spectrum of behaviors and
traits characterized by behavioral disinhibition. This externalizing spectrum includes …

Background The children of parents who abuse alcohol typically show reduced amplitude of
the P3 event-related potential wave. We determined if this effect was present in a population …

Objective: The development of substance use disorder (SUD) was prospectively
investigated in 66 boys having fathers with SUD and 104 boys having fathers with no adult …

Reduced P300 amplitude is reliably found in individuals with a personal or family history of
alcohol problems. However, alcoholism is part of a broader externalizing spectrum that …

The goal of basic human neuroscience research is to understand psychological processes
in terms of the structure and functioning of underlying neurobiological systems. In parallel …

Objective: The authors investigated whether the transition from licit drug use to marijuana
use is determined by particular risk factors, as specified by the gateway hypothesis. They …

Approximately 5% of adolescents in the US qualify for a diagnosis of substance use disorder
(SUD). Low affect and behavior self-regulation during child development interacting with …

Individuals with a substance use disorder (SUD) exhibit deficits in executive cognitive
functioning (ECF). ECF is involved in the regulation of goal-directed behavior and includes …

We propose that neuroscientific understanding of antisocial behavior can be advanced by
focusing programmatic efforts on neurobehavioral trait constructs, that is, individual …