It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

Evidence for the importance of zinc for all immune cells and for mounting an efficient and
balanced immune response to various environmental stressors has been accumulating in …

Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate
zinc-binding group (ZBG). However, more recent work has shown that the use of alternative …

Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

As “Michael acceptors” may induce promiscuous responses in mammalian cells by reacting
with various proteins, we modified the cinnamamide of our previous hydrazide-based HDAC …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …

The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

Lysine acetylation in histone tails is a key post-translational modification that controls
transcription activation. Histone deacetylase complexes remove histone acetylation, thereby …

Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …