The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

The intestinal tract is the largest barrier between a person and the environment. In this role,
the intestinal tract is responsible not only for absorbing essential dietary nutrients, but also …

Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases
(IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut …

The intestinal barrier is a structure that prevents harmful substances, such as bacteria and
endotoxins, from penetrating the intestinal wall and entering human tissues, organs, and …

Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in
maintaining intestinal barrier functions and thus preventing diffusion of small molecules and …

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Destruction in intestinal barrier is concomitant with the intestinal diseases. There is growing
evidence that tryptophan-derived intestinal bacterial metabolites play a critical role in …

Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, which is
closely related to gut barrier dysfunction. Emerging evidence shows that interleukin-22 (IL …

FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based
chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer …

Increased inflammation associated with leaky gut is a major risk factor for morbidity and
mortality in older adults; however, successful preventive and therapeutic strategies against …