Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

Abstract siRNA‐mediated management of myocardial ischemia reperfusion (IR) injury is
greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection …

Background: Human engineered heart tissue (EHT) transplantation represents a potential
regenerative strategy for patients with heart failure and has been successful in preclinical …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …