In this review, the potential causes and consequences of adult height, a measure of cumulative net nutrition, in modern populations are summarized. The mechanisms linking …
Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing …
SV Ramagopalan, R Dobson, UC Meier… - The Lancet …, 2010 - thelancet.com
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of MS is not yet known, although epidemiological data indicate that both genetic and …
AT Nguyen, Y Zhang - Genes & development, 2011 - genesdev.cshlp.org
DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …
The organization of eukaryotic genomes into chromatin provides challenges for the cell to accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …
EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
Through epigenetic modifications, specific long-term phenotypic consequences can arise from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
CT Watson, P Roussos, P Garg, DJ Ho, N Azam… - Genome medicine, 2016 - Springer
Background Alzheimer's disease affects~ 13% of people in the United States 65 years and older, making it the most common neurodegenerative disorder. Recent work has identified …
A growing body of evidence points towards epigenetic mechanisms being responsible for a wide range of biological phenomena, from the plasticity of plant growth and development to …
AW Drong, CM Lindgren… - Clinical Pharmacology & …, 2012 - Wiley Online Library
Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. The evidence for familial aggregation of both T2D and obesity is substantial. To …