Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
Anogenital distance as a marker of androgen exposure in humans
Abnormal foetal testis development has been proposed to underlie common disorders of the
male reproductive system such as cryptorchidism, hypospadias, reduced semen quality and …
male reproductive system such as cryptorchidism, hypospadias, reduced semen quality and …
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
Using human genetics to understand the disease impacts of testosterone in men and women
Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …
health and body composition, yet its effects on disease outcomes are unknown. To better …
[HTML][HTML] Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
[HTML][HTML] Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal …
RN Beaumont, NM Warrington… - Human molecular …, 2018 - academic.oup.com
Genome-wide association studies of birth weight have focused on fetal genetics, whereas
relatively little is known about the role of maternal genetic variation. We aimed to identify …
relatively little is known about the role of maternal genetic variation. We aimed to identify …
[HTML][HTML] Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
CS Gallagher, N Mäkinen, HR Harris… - Nature …, 2019 - nature.com
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract
and primary cause for hysterectomy, leading to considerable morbidity and high economic …
and primary cause for hysterectomy, leading to considerable morbidity and high economic …
[HTML][HTML] Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes
Sex differences have been widely observed in human health. However, little is known about
the underlying mechanism behind these observed sex differences. We hypothesize that sex …
the underlying mechanism behind these observed sex differences. We hypothesize that sex …
[HTML][HTML] A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …
data from large endometriosis and EOC genome-wide association meta-analyses, we …