The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins
throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a …

Integration of retroviral reverse transcripts into the chromosomes of the cells that they infect
is required for efficient viral gene expression and the inheritance of viral genomes to …

Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …

The human immunodeficiency virus (HIV) infection of the immune cells expressing the
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …

The integration of retroviral reverse transcripts into the chromatin of the cells that they infect
is required for virus replication. Retroviral integration has far-reaching consequences, from …

The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207).
We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection. HIV …

The movement of viruses and other large macromolecular cargo through nuclear pore
complexes (NPCs) is poorly understood. The human immunodeficiency virus type 1 (HIV-1) …

A rapidly evolving understanding of phase separation in the biological and physical
sciences has led to the redefining of virus-engineered replication compartments in many …

Host restriction factors affect different phases of a viral life cycle, contributing to innate
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …

Abstract HIV-1 capsid (CA) plays indispensable and multiple roles in the life cycle of HIV-1,
become an attractive target in antiviral therapy. Herein, we report the design, synthesis, and …