Altered HIV-1 viral copy number and gene expression profiles of peripheral (CEM CCR5+) and mucosal (A3R5. 7) T cell lines co-infected with HSV-2 in vitro
D Desai, R Londhe, M Chandane, S Kulkarni - Viruses, 2022 - mdpi.com
Co-infecting pathogens have been speculated to influence Human Immunodeficiency Virus
(HIV) disease progression. Herpes Simplex Virus Type-2 (HSV-2), another sexually …
(HIV) disease progression. Herpes Simplex Virus Type-2 (HSV-2), another sexually …
Defining the HIV capsid binding site of nucleoporin 153
The interaction between the HIV-1 capsid and human nucleoporin 153 (NUP153) is vital for
delivering the HIV-1 preintegration complex into the nucleus via the nuclear pore complex …
delivering the HIV-1 preintegration complex into the nucleus via the nuclear pore complex …
Label-free imaging of nuclear membrane for analysis of nuclear import of viral complexes
A Ten Eyck, YC Chen, L Gifford, D Torres-Rivera… - Journal of Virological …, 2023 - Elsevier
HIV-1 enters the nucleus of non-dividing cells through the nuclear pore complex where it
integrates into the host genome. The mechanism of HIV-1 nuclear import remains poorly …
integrates into the host genome. The mechanism of HIV-1 nuclear import remains poorly …
Advances in the understanding of nuclear pore complexes in human diseases
Y Li, J Zhu, F Zhai, L Kong, H Li, X Jin - Journal of Cancer Research and …, 2024 - Springer
Abstract Background Nuclear pore complexes (NPCs) are sophisticated and dynamic
protein structures that straddle the nuclear envelope and act as gatekeepers for transporting …
protein structures that straddle the nuclear envelope and act as gatekeepers for transporting …
Direct tracking of single proviruses reveals HIV-1/LEDGF complexes excluded from virus-induced membraneless organelles
V Scoca, M Louveaux, R Morin, D Ershov, JY Tinevez… - bioRxiv, 2020 - biorxiv.org
HIV integration occurs in chromatin sites that favor the release of high levels of viral progeny,
alternatively the virus is also able to coexist discreetly with the host. To uncover the HIV-1 …
alternatively the virus is also able to coexist discreetly with the host. To uncover the HIV-1 …
CA mutation N57A has distinct strain-specific HIV-1 capsid uncoating and infectivity phenotypes
DK Fischer, A Saito, C Kline, R Cohen… - Journal of …, 2019 - Am Soc Microbiol
The ability of human immunodeficiency virus type 1 (HIV-1) to transduce nondividing cells is
key to infecting terminally differentiated macrophages, which can serve as a long-term …
key to infecting terminally differentiated macrophages, which can serve as a long-term …
Characterization of Nuclear HIV-Induced Membraneless Organelles Through Fluorescence Microscopy
V Scoca, F Di Nunzio - HIV Protocols, 2024 - Springer
The postnuclear entry steps of HIV-1 involve reverse transcription, uncoating, and
integration into the host genome. The differential regulation of these steps has a significant …
integration into the host genome. The differential regulation of these steps has a significant …
PF74 and its novel derivatives stabilize hexameric lattice of HIV-1 mature-like particles
A Dostálková, K Škach, F Kaufman, I Křížová… - Molecules, 2020 - mdpi.com
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two
different hexameric lattices, which makes this protein a key component for both the early and …
different hexameric lattices, which makes this protein a key component for both the early and …
TRIM5α restriction of HIV-1-N74D viruses in lymphocytes is caused by a loss of cyclophilin A Protection
A Selyutina, LM Simons, KA Kirby, A Bulnes-Ramos… - Viruses, 2022 - mdpi.com
The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the
human protein CPSF6. In primary human CD4+ T cells, HIV-1-N74D viruses exhibit an …
human protein CPSF6. In primary human CD4+ T cells, HIV-1-N74D viruses exhibit an …
Potency and metabolic stability: A molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein
PF74 (1) is a potent and well-characterized prototypical small molecule targeting human
immunodeficiency virus type 1 (HIV-1) capsid protein (CA), but not a viable antiviral lead due …
immunodeficiency virus type 1 (HIV-1) capsid protein (CA), but not a viable antiviral lead due …