Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …

DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …

Background Hepatocellular carcinoma (HCC) is the one of the most common cancers and
lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and …

Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …