Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum–a systematic review with …

S Buckley, K Uvnäs-Moberg, Z Pajalic… - BMC pregnancy and …, 2023 - Springer
Background The reproductive hormone oxytocin facilitates labour, birth and postpartum
adaptations for women and newborns. Synthetic oxytocin is commonly given to induce or …

Endometrial microbiota and immune tolerance in pregnancy

A Inversetti, E Zambella, A Guarano… - International Journal of …, 2023 - mdpi.com
Recent studies have demonstrated that the uterus has its own microbiota. However, there is
no consensus on endometrial microbiota composition, thus its role in the healthy uterine …

New medicines for spontaneous preterm birth prevention and preterm labour management: landscape analysis of the medicine development pipeline

ARA McDougall, R Hastie, M Goldstein, A Tuttle… - BMC Pregnancy and …, 2023 - Springer
Background There are few medicines in clinical use for managing preterm labor or
preventing spontaneous preterm birth from occurring. We previously developed two target …

“Iron triangle” of regulating the uterine microecology: Endometrial microbiota, immunity and endometrium

N Zhu, X Yang, Q Liu, Y Chen, X Wang, H Li… - Frontiers in …, 2022 - frontiersin.org
The uterus is the core place for breeding new life. The balance and imbalance of uterine
microecology can directly affect or even dominate the female reproductive health. Emerging …

[HTML][HTML] The physiology and pharmacology of oxytocin in labor and in the peripartum period

K Uvnäs-Moberg - American Journal of Obstetrics and Gynecology, 2023 - Elsevier
Oxytocin is a reproductive hormone implicated in the process of parturition and widely used
during labor. Oxytocin is produced within the supraoptic nucleus and paraventricular …

Is human labor at term an inflammatory condition?

C Kyathanahalli, M Snedden, E Hirsch - Biology of reproduction, 2023 - academic.oup.com
Parturition at term in normal pregnancy follows a predictable sequence of events. There is
some evidence that a state of inflammation prevails in the reproductive tissues during labor …

The role of gonadal hormones in regulating opioid antinociception

Q Xu, L Jin, LY Wang, YY Tang, H Wu, Q Chen… - Annals of …, 2024 - Taylor & Francis
Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical
studies have reported strong evidence for sex-related divergence regarding opioid …

Polycystic ovary syndrome and the forgotten uterus

P Hosseinzadeh, M Barsky, WE Gibbons, CS Blesson - F&S Reviews, 2021 - Elsevier
Objective To review the features of endometrial and uterine aberrations in women with
Polycystic ovary syndrome (PCOS). Evidence Review PCOS is a common disorder that …

Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium

L Riaposova, SH Kim, AC Hanyaloglu… - Frontiers in …, 2023 - frontiersin.org
Introduction Preterm birth is one of the major causes of neonatal morbidity and mortality
across the world. Both term and preterm labour are preceded by inflammatory activation in …

The role (s) of eicosanoids and exosomes in human parturition

E Mosaad, HN Peiris, O Holland… - Frontiers in …, 2020 - frontiersin.org
The roles that eicosanoids play during pregnancy and parturition are crucial to a successful
outcome. A better understanding of the regulation of eicosanoid production and the roles …