Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

The management of skin cancer in solid organ transplant recipients is a challenge to both
the dermatologist and transplant physician. Part II of this continuing medical education …

The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …

Transgenic animals are extensively used to study in vivo gene function as well as to model
human diseases. The technology for producing transgenic animals exists for a variety of …

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

The complement system is a key element of the innate immune system, and the production
of complement components can be divided into central (hepatic) and peripheral …

Of the numerous animal models available for proteomic studies only a small number have
been successfully used in understanding human biology. To date, rodents have been widely …

Despite increasing donor numbers, waiting lists and pre‐transplant mortality continue to
grow in many countries. The number of donor organs suitable for liver transplantation is …

Liver disease affects millions of patients each year. The field of regenerative medicine
promises alternative therapeutic approaches, including the potential to bioengineer …

Swine leucocyte antigen (SLA) class II molecules on porcine (p) cells play a crucial role in
xenotransplantation as activators of recipient human CD4+ T cells. A human dominant …