In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human
decedents did not show evidence of acute-onset cellular-or antibody-mediated rejection …

While extensive research using animal models has improved the understanding of acute
kidney injury (AKI), this knowledge has not been translated into effective treatments. Many …

The shortage of donor lungs for transplantation causes a significant number of patient
deaths. The availability of laboratory engineered, functional organs would be a major …

Background The programmed cell death‐1 (PD‐1, CD 279)/PD‐Ligand1 (PD‐L1, CD 274)
receptor system is crucial for controlling the balance between immune activation and …

The transplantation of organs across species offers the potential to solve the shortage of
human organs. While activation of human platelets by human von Willebrand factor (vWF) …

The prevalence of heart failure is increasing, and the prognosis of end-stage heart failure
remains dismal. The gold-standard therapy in end-stage heart failure remains cardiac …

Cooper DKC, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, Tector AJ, Phelps C,
Azimzadeh AM, Ayares D, Robson SC, Pierson RN III. Clinical lung xenotransplantation …

In the past 20 y, the number of patients in the United States who died while waiting for a
human donor liver totaled> 52 000. The median national wait time for patients with acute …

Background Xenotransplantation is a worth investing branch of science, since it aims to fulfil
the demand on human cells, tissues and organs. Despite decades of consistent work in …

Cardiac troponin I (cTnI) is an important regulatory protein in cardiac muscle, and its
modification represents a key mechanism in the regulation of cardiac muscle contraction …