Exploiting nature's rich source of proteasome inhibitors as starting points in drug development

MA Gräwert, M Groll - Chemical Communications, 2012 - pubs.rsc.org
Cancer is the No. 2 cause of death in the Western world and one of the most expensive
diseases to treat. Thus, it is not surprising, that every major pharmaceutical and …

Suppression of human macrophage-mediated cytotoxicity by transgenic swine endothelial cell expression of HLA-G

EL Esquivel, A Maeda, H Eguchi, M Asada… - Transplant …, 2015 - Elsevier
Background Xenotransplantation is an appealing alternative to human allotransplantation
because of a worldwide shortage of organs. One of the obstacles for xenografts is cellular …

Comparison of hematologic, biochemical, and coagulation parameters in α1, 3‐galactosyltransferase gene‐knockout pigs, wild‐type pigs, and four primate species

B Ekser, J Bianchi, S Ball, H Iwase… - …, 2012 - Wiley Online Library
Ekser B, Bianchi J, Ball S, Iwase H, Walters A, Ezzelarab M, Veroux M, Gridelli B, Wagner R,
Ayares D, Cooper DKC. Comparison of hematologic, biochemical, and coagulation …

Porcine to human heart transplantation: is clinical application now appropriate?

CGA McGregor, GW Byrne - Journal of immunology research, 2017 - Wiley Online Library
Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor
hearts. Recent advancements in immune suppression have greatly improved the survival of …

Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection

TH Kim, JJ Yan, JY Jang, GM Lee, SK Lee, BS Kim… - Science …, 2021 - science.org
Most of the vascular platforms currently being studied are lab-on-a-chip types that mimic
capillary networks and are applied for vascular response analysis in vitro. However, these …

Increased transfusion‐free survival following auxiliary pig liver xenotransplantation

H Yeh, Z Machaidze, I Wamala, JW Fraser… - …, 2014 - Wiley Online Library
Background Pig to baboon liver xenotransplantation typically results in severe
thrombocytopenia and coagulation disturbances, culminating in death from hemorrhage …

[HTML][HTML] Long-term high intake of whole proteins results in renal damage in pigs

Y Jia, SY Hwang, JD House, MR Ogborn… - The Journal of …, 2010 - Elsevier
Despite evidence of potential antiobesity effects of high-protein (HP) diets, the impact of
consuming diets with protein levels at the upper limit of the acceptable macronutrient …

Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?

B Ekser, B Gridelli, AJ Tector, DKC Cooper - Transplantation, 2009 - journals.lww.com
Acute liver failure is a potentially devastating clinical syndrome that, without liver
transplantation (Tx), is associated with high mortality. Rapid deterioration in clinical status …

[HTML][HTML] Human immune-cell response towards diverse xenogeneic and allogeneic decellularized biomaterials

E Rieder, A Steinacher-Nigisch, G Weigel - International Journal of Surgery, 2016 - Elsevier
Background Immunological knowledge on processed biological implants and mesh-
prostheses is still mainly based on animal models, lacking information on the species …

Research prospects for kidney xenotransplantation: a bibliometric analysis

S Yang, M Zhang, H Wei, B Zhang, J Peng, P Shang… - Renal …, 2024 - Taylor & Francis
Background Xenograft kidney transplantation has been receiving increasing attention. The
purpose of this study is to use bibliometric analysis to identify papers in this research field …