Organ transplantation represents a unique method of treatment to cure people with end-
stage organ failure. Since the first successful organ transplant in 1954, the field of …

The vascular and coagulation issues in xenotransplantation : Current Opinion in Organ
Transplantation The vascular and coagulation issues in xenotransplantation : Current Opinion …

Drug metabolism is a core determinant of the dose–effectiveness–toxicity relationship of
many compounds. It is also critical to the human food safety assessment of drug residues in …

Genetically modified porcine models of pig-to-human xenotransplantation offer the most
immediate answer to a growing shortage of available solid organs. Recently a modified …

In theory, about 95% of one animal is usable. The remaining 5% is processing losses. From
that 95%, about 55%(on average) of the animal is used for edible products and the …

Hyperacute rejection (HAR) depends on the response of xenoreactive antibodies principally
against porcine α-Gal epitope. Methods eliminating HAR include GGTA1 inactivation …

OBJECTIVE: To validate the use of a microelectronic real-time cell analyzer system (RTCA)
we developed a complement-mediated antibody cytotoxicity assay to investigate the …

Background. We set out to determine whether B-cell tolerance to A/B-incompatible
alloantigens and pig xenoantigens could be achieved in infant baboons. Methods. Artery …

Background Porcine endogenous retrovirus (PERV) poses a potential risk of zoonotic
infection in xenotransplantation. Preclinical transplantation trials using non-human primates …

Xenotransplantation of solid organs will only ever become a clinical reality with genetic
modification of the pig, which is now widely accepted as the most likely donor species for …