Existing strategies for repair of major peripheral nerve injury (PNI) are inefficient at
promoting axon regeneration and functional recovery and are generally ineffective for nerve …

Organ transplant is a crucial therapeutic strategy offering a life‐saving and transformative
medical intervention. It provides an opportunity to improve their quality of life and increase …

ABSTRACT Background In South Korea, pig-to-nonhuman primate trials of solid organs
have only been performed recently, and the results are not sufficiently satisfactory to initiate …

Xenotransplantation of pig organs into primates leads to hyperacute rejection (HAR).
Functional ablation of the pig α 1, 3-galactosyltransferase (GalT) gene, which abrogates …

Background Xenotransplantation is a promising approach to circumventing the current
organ shortage. However, T-cell-dependent anti-xenoresponses are a major challenge to …

Background Solid organ xenotransplantation is a potential solution to current organ
shortages in allotransplantation. We performed four heart transplantations from alpha1, 3 …

Objective: Generation of human livers in pigs might improve the serious shortage of grafts for
human liver transplantation, and enable liver transplantation without the need for deceased …

Pig adipose mesenchymal stem cells (AMSCs) could be proposed for the improvement of
bone substitute. However, these xenogenic cells retain a galactosyl (Gal) epitope that elicits …

Genetically engineered pigs serve as excellent biomedical and agricultural models. To date,
the most reliable way to generate genetically engineered pigs is via somatic cell nuclear …

Background Despite the economic and medical importance of the pig, knowledge about its
genome organization, gene expression regulation, and molecular mechanisms involved in …