Neglected diseases are a major global cause of illness, long-term disability and death.
Chagas' disease is a parasitic infection widely distributed throughout Latin America, with …

A fundamental postulate in the classical drug design paradigm is that the effect of a drug in
the human body is a consequence of the molecular recognition between a ligand (the drug) …

A sensor based on a carbon glassy electrode modified with hemin complex and multi-walled
carbon nanotubes (MWCNT) was developed as an alternative technique to evaluate the …

A series of indazole N-oxide derivatives have been synthesized and their antichagasic and
leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide …

Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines can
be considered as ethylenediamine/carbonyl precursors and therefore interfere with the …

As a continuation of our research and with the aim of obtaining new agents against Chagas
disease, an extremely neglected disease which threatens 100 million people, eighteen new …

Searching for new promising metal-based hits against Trypanosoma cruzi and Leishmania
parasites, two related oxidovanadium (IV) N-acylhydrazone complexes,[VIVO …

For a fourth approach of quinoxaline N, N′-dioxides as anti-trypanosomatid agents against
T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us …

Since the synthesis of 4, 6-dinitrobenzofuroxan in 1899 by Drost, benzofuroxans have
attracted particular attention. This peculiar series of compounds exhibit a broad spectrum of …

Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were
designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed …