ABSTRACT Pradofloxacin (PRA) is an 8-cyano-fluoroquinolone (FQ) being developed to
treat bacterial infections in dogs and cats. Its mutant prevention concentrations (MPC) were …

Microarray-based comparative genome hybridisations (CGH) and genome sequencing of
Clostridium difficile isolates have shown that the genomes of this species are highly …

Objectives: To study the in vitro interaction of gatifloxacin in combination with gentamicin
and with the β-lactams cefepime, meropenem and piperacillin against clinical isolates of …

Background/Aim: Ciprofloxacin has been used as an antibiotic in the clinic for decades.
Recently, ciprofloxacin and its derivatives have shown promising anti-proliferative and …

Abstract Development of new derivatives of commercial antibiotics using different organic
reagents and testing these derivatives against different microorganisms are the main goals …

Objective. This study was designed to test whether rotation of antibiotics can reduce
colonization with resistant Gram-negative bacilli in a neonatal intensive care unit (NICU) …

Drug-resistant bacterial infections and lack of available antibacterial agents in clinical
practice are becoming serious risks to public health. We synthesized a new class of …

This study aimed to investigate the prevalence of resistance to second-line antituberculosis
(anti-TB) drugs and its association with resistance-related mutations in Mycobacterium …

This paper reports on the rational design of a series of new 6-fluoroquinolones by QSAR
analysis against Toxoplasma (T.) gondii, their synthesis, their biological evaluation against …

When bacterial cells are exposed to increasing concentrations of quinolone-class
antibacterials, survival drops, reaches a minimum, and then recovers, sometimes to 100 …