Pancreatic cancer (PC) has one of the highest fatality rates and the currently available
therapeutic options are not sufficient to improve its overall poor prognosis. In addition to …

Pancreatic cancer is an aggressive malignant tumor with high mortality and a low survival
rate. The immune and stromal cells that infiltrate in the tumor microenvironment (TME) …

Simple Summary Pancreatic cancer is an aggressive disease with most patients diagnosed
at late stages resulting in poor outcomes. While it is known that pancreatic tumor cells …

Simple Summary The tumor microenvironment of pancreatic cancer consists of dense
fibrotic stroma, which, to a certain extent, accounts for the relative drug resistance of this …

High saturated fat diets have been shown to raise blood levels of cholecystokinin (CCK) and
induce nonalcoholic steatohepatitis (NASH). CCK receptors are expressed on stellate cells …

The poor prognosis for pancreatic ductal adenocarcinoma (PDAC) patients is due in part to
the highly fibrotic nature of the tumors that impedes delivery of therapeutics, including …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated deaths
worldwide. Treatment with immune checkpoint antibodies has shown promise in advanced …

Survival from pancreatic cancer is poor because most cancers are diagnosed in the late
stages and there are no therapies to prevent the progression of precancerous pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy wherein a majority
of patients present metastatic disease at diagnosis. Although the role of epithelial to …