This study aimed to clarify the differential exercise capacity between 2-month-old and 10-
month-old mice using an incremental running test. Metabolic and ventilatory responses and …

Abstract Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative
and inflammatory stress and consequently a shorter lifespan than Exceptional Non …

Objectives Exercise is assumed to attenuate age-related neuronal apoptosis, but the
detailed mechanism (s) is not fully understood. α1-Adrenergic receptors (ARs) can either …

Aging significantly elevates the risk for Alzheimer′ s disease (AD), contributing to the
accumulation of AD pathologies, such as amyloid-β (Aβ), inflammation, and oxidative stress …

Tauopathies belong to a heterogeneous class of neuronal diseases resulting in the
metabolic disturbance. A disulfide natural compound of Alpha-Lipoic acid (ALA) has shown …

Across species, spatial memory declines with age, possibly reflecting altered hippocampal
and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network …

Significance: Reactive species have been classically considered causative of age-related
degenerative processes, but the scenario appears considerably more complex and to some …

Background: Changes in both circulating cytokines and neurochemical concentrations have
been observed in aging. Patterns of change across these factors are associated with age …

Background Brain aging is associated with an excessive reactive oxygen species (ROS)
formation that causes cell injury through proteins oxidation and DNA damage. These …

The increase in life expectancy is one of the highest accomplishments of humankind. Yet,
this situation is also one of the most challenging public health issues. Despite the inevitable …