Exploring the role of glycolytic enzymes PFKFB3 and GAPDH in the modulation of Aβ and neurodegeneration and their potential of therapeutic targets in Alzheimer's …

I Ahmad, R Singh, S Pal, S Prajapati, N Sachan… - Applied Biochemistry …, 2023 - Springer
Alzheimer's disease (AD) is presently the 6th major cause of mortality across the globe.
However, it is expected to rise rapidly, following cancer and heart disease, as a leading …

Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress‐dependent neuronal death

V Castelli, F Melani, C Ferri, M d'Angelo… - Journal of cellular …, 2020 - Wiley Online Library
Oxidative stress is considered the common effector of the cascade of degenerative events in
many neurological conditions. Thus, in this paper we tested different nutraceuticals in H2O2 …

[HTML][HTML] Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl3 Toxicity in Rats

ZAS Hawash, EM Yassien, BS Alotaibi… - Toxics, 2023 - mdpi.com
Jambolan fruit extract and choline were investigated for Aluminum tri chloride (AlCl3)-
induced Alzheimer's disease in rats. Thirty-six male “Sprague Dawley” rats weighing …

[HTML][HTML] Current perspective of hydrogen sulfide as a novel gaseous modulator of oxidative stress in glaucoma

Y Feng, V Prokosch, H Liu - Antioxidants, 2021 - mdpi.com
Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion
cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation …

[HTML][HTML] Inhibition of nigral microglial activation reduces age-related loss of dopaminergic neurons and motor deficits

TF Wang, SY Wu, BS Pan, SF Tsai, YM Kuo - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is an age-related neurodegenerative disease caused by a
selective loss of dopaminergic (DA) neurons in the substantia nigra (SN). Microglial …

Interactive Effects of Swimming High‐Intensity Interval Training and Resveratrol Supplementation Improve Mitochondrial Protein Levels in the Hippocampus of Aged …

M Amirazodi, F Daryanoosh, A Mehrabi… - BioMed Research …, 2022 - Wiley Online Library
Mitochondrial dysfunction and increased oxidative stress cause damage to cells which can
lead to the aging process and age‐related diseases. Antioxidants such as resveratrol and …

[HTML][HTML] Biomolecular modifications linked to oxidative stress in amyotrophic lateral sclerosis: Determining promising biomarkers related to oxidative stress

T Hosaka, H Tsuji, A Tamaoka - Processes, 2021 - mdpi.com
Reduction–oxidation reactions are essential to cellular homeostasis. Oxidative stress
transcends physiological antioxidative system damage to biomolecules, including nucleic …

Effects of dietary supplements, foods, and dietary patterns in Parkinson's disease: meta-analysis and systematic review of randomized and crossover studies

L Wu, L Chu, Y Pang, J Huo, H Cao, Q Tian… - European Journal of …, 2024 - nature.com
Abstract Background Diet significantly impacts Parkinson's disease (PD) with plausible
biological hypotheses. Although the thesis has been explored in several human clinical …

[HTML][HTML] Pharmacological effect of caffeine on drosophila melanogaster: a proof-of-concept in vivo study for nootropic investigation

A Asbah, U Ummussaadah, N Parenden… - Archives of Razi …, 2021 - ncbi.nlm.nih.gov
A comprehensive investigation into drug candidates with nootropic activity using a proper
and high throughput yet economical model organism is an important issue to consider. This …

[HTML][HTML] Resting-state functional connectivity of the ageing female brain—differences between young and elderly female adults on multislice short TR Rs-fMRI

P Podgórski, M Waliszewska-Prosół, A Zimny… - Frontiers in …, 2021 - frontiersin.org
Introduction: Age-related brain changes are one of the most important world health problems
due to the rising lifespan and size of the elderly populations. The aim of the study was to …