The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Twenty years after the discovery of sarcolemmal ATP-sensitive K+ channels and 12 years
after the discovery of mitochondrial KATP (mitoKATP) channels, progress has been …

Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels
rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or …

Programmed cell death or apoptosis is broadly responsible for the normal homeostatic
removal of cells and has been increasingly implicated in mediating pathological cell loss in …

In work spanning more than a century, mitochondria have been recognized for their
multifunctional roles in metabolism, energy transduction, ion transport, inheritance …

Opening of the mitochondrial permeability transition pore (MPTP) is thought to be a critical
event in mediating the damage to hearts that accompanies their reperfusion following …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …