Benchmarking spatial clustering methods with spatially resolved transcriptomics data

Z Yuan, F Zhao, S Lin, Y Zhao, J Yao, Y Cui… - Nature …, 2024 - nature.com
Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Stgnnks: identifying cell types in spatial transcriptomics data based on graph neural network, denoising auto-encoder, and k-sums clustering

L Peng, X He, X Peng, Z Li, L Zhang - Computers in Biology and Medicine, 2023 - Elsevier
Background: Spatial transcriptomics technologies fully utilize spatial location information,
tissue morphological features, and transcriptional profiles. Integrating these data can greatly …

Integrating spatial transcriptomics data across different conditions, technologies and developmental stages

X Zhou, K Dong, S Zhang - Nature Computational Science, 2023 - nature.com
With the rapid generation of spatial transcriptomics (ST) data, integrative analysis of multiple
ST datasets from different conditions, technologies and developmental stages is becoming …

Spatial transcriptomics prediction from histology jointly through transformer and graph neural networks

Y Zeng, Z Wei, W Yu, R Yin, Y Yuan, B Li… - Briefings in …, 2022 - academic.oup.com
The rapid development of spatial transcriptomics allows the measurement of RNA
abundance at a high spatial resolution, making it possible to simultaneously profile gene …

Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding

R Shen, L Liu, Z Wu, Y Zhang, Z Yuan, J Guo… - Nature …, 2022 - nature.com
Spatially resolved transcriptomics provides the opportunity to investigate the gene
expression profiles and the spatial context of cells in naive state, but at low transcript …

MENDER: fast and scalable tissue structure identification in spatial omics data

Z Yuan - Nature Communications, 2024 - nature.com
Tissue structure identification is a crucial task in spatial omics data analysis, for which
increasingly complex models, such as Graph Neural Networks and Bayesian networks, are …

Streamlining spatial omics data analysis with Pysodb

S Lin, F Zhao, Z Wu, J Yao, Y Zhao, Z Yuan - Nature Protocols, 2024 - nature.com
Advances in spatial omics technologies have improved the understanding of cellular
organization in tissues, leading to the generation of complex and heterogeneous data and …

SOTIP is a versatile method for microenvironment modeling with spatial omics data

Z Yuan, Y Li, M Shi, F Yang, J Gao, J Yao… - Nature …, 2022 - nature.com
The rapidly developing spatial omics generated datasets with diverse scales and modalities.
However, most existing methods focus on modeling dynamics of single cells while ignore …

Identifying spatial domains of spatially resolved transcriptomics via multi-view graph convolutional networks

X Shi, J Zhu, Y Long, C Liang - Briefings in Bioinformatics, 2023 - academic.oup.com
Motivation: Recent advances in spatially resolved transcriptomics (ST) technologies enable
the measurement of gene expression profiles while preserving cellular spatial context …

Latent feature extraction with a prior-based self-attention framework for spatial transcriptomics

Z Li, X Chen, X Zhang, R Jiang, S Chen - Genome Research, 2023 - genome.cshlp.org
Rapid advances in spatial transcriptomics (ST) have revolutionized the interrogation of
spatial heterogeneity and increase the demand for comprehensive methods to effectively …