Among the hereditary ataxias, autosomal recessive spinocerebellar ataxias comprise a
diverse group of neurodegenerative disorders. Clinical phenotypes vary from predominantly …

Adverse reactions to radiotherapy represent a confounding phenomenon in radiation
oncology. These reactions are rare, and many have been associated with individuals with …

Cancer and neurodegeneration are often thought of as disease mechanisms at opposite
ends of a spectrum; one due to enhanced resistance to cell death and the other due to …

Purpose: Radiotherapy is an effective cancer treatment, but a few patients suffer severe
radiation toxicities in neighboring normal tissues. There is increasing evidence that the …

It has been hypothesized that oncogenesis and neurodegeneration may share common
mechanistic foundations. Recent evidence now reveals a number of genes in which …

ABSTRACT Introduction: Ataxia-telangiectasia (AT) a multisystem disorder primarily
characterized by cerebellar degeneration, telangiectasia, immunodeficiency, cancer …

Ataxia telangiectasia (AT) is a rare neurodegenerative, autosomal recessive disorder
characterized by chromosome instability, radiosensitivity, immunodeficiency and a …

The first description of patients with ataxia–telangiectasia (AT) was published in French in
1926 by the internist Ladislav Syllaba and the neurologist Kamil Henner (Syllaba and …

ALC1/CHD1L is a member of the SNF2 superfamily of ATPases carrying a macrodomain
that binds poly (ADP-ribose). Poly (ADP-ribose) polymerase (PARP) 1 and 2 synthesize poly …

PURPOSE: To evaluate, in a pilot study, the phosphorylated H2AX (γH2AX) foci approach
for identifying patients with double-strand break (DSB) repair deficiencies, who may …