Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is associated with the regulation of essential cellular mechanisms, such as …

Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic
infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition …

Central and peripheral interventions for brain injury rehabilitation have been widely
employed. However, as patients' requirements and expectations for stroke rehabilitation …

Stroke, in association with its complications, is one of the leading causes of mortality and
morbidity worldwide. Cerebral ischemia triggers an inflammatory response in the brain that …

Recombinant HIV-1 envelope (Env) glycoproteins of ever-increasing sophistication have
been evaluated as vaccine candidates for over 30 years. Structurally defined mimics of …

Introduction: In recent years, purinergic signaling via the P2X7 receptor (P2X7R) on
microglia has repeatedly been implicated in depression genesis. However, it remains …

Emerging respiratory viruses are major health threats due to their potential to cause massive
outbreaks. Over the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has …

With few exceptions, humans are incapable of fully recovering from severe physical trauma.
Due to these limitations, the field of regenerative medicine seeks to find clinically viable …

Psoriasis is a skin disease characterized by epidermal hyperplasia and an inappropriate
activation of the adaptive immunity. A dysregulation of the skin's lipid mediators is reported …