Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor
expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and …

Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …

Key points Pharmacological and molecular inhibition of transient receptor potential
melastatin 7 (TRPM7) reduces store‐operated calcium entry (SOCE). Overexpression of …

B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical
immune-regulatory functions. Acquisition of functional specificity requires that a cell survive …

The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for
effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity …

TRIM family proteins play integral roles in the innate immune response to virus infection.
MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific …

Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated
Ca 2+(CRAC) channels in T cells is well established. In contrast, the contribution of …

Abstract B-cell receptor (BCR)-mediated antigen internalization and presentation are
essential for humoral memory immune responses. Antigen encountered by B-cells is often …