Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …

A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation …

In addition to the immune system's traditional roles of conferring anti-infectious and anti-
neoplastic protection, it has been recently implicated in the regulation of systemic metabolic …

Obesity is a highly heritable disease driven by complex interactions between genetic and
environmental factors. Human genome-wide association studies (GWAS) have identified a …

The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …

The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …

The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …

Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …