Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
JA Timmons, S Knudsen, T Rankinen… - Journal of applied …, 2010 - journals.physiology.org
A low maximal oxygen consumption (V̇o2max) is a strong risk factor for premature
mortality. Supervised endurance exercise training increases V̇o2max with a very wide …
mortality. Supervised endurance exercise training increases V̇o2max with a very wide …
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
While there have been studies exploring regulatory variation in one or more tissues, the
complexity of tissue-specificity in multiple primary tissues is not yet well understood. We …
complexity of tissue-specificity in multiple primary tissues is not yet well understood. We …
Weighted gene coexpression network analysis: state of the art
Weighted gene coexpression network analysis (WGCNA) has been applied to many
important studies since its introduction in 2005. WGCNA can be used as a data exploratory …
important studies since its introduction in 2005. WGCNA can be used as a data exploratory …
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer
G Zhang, P He, H Tan, A Budhu, J Gaedcke… - Clinical cancer …, 2013 - AACR
Purpose: To identify metabolic pathways that are perturbed in pancreatic ductal
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of …
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of …
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
A key goal of biology is to construct networks that predict complex system behavior. We
combine multiple types of molecular data, including genotypic, expression, transcription …
combine multiple types of molecular data, including genotypic, expression, transcription …
Host–microbial interactions in idiopathic pulmonary fibrosis
PL Molyneaux, SAG Willis-Owen, MJ Cox… - American journal of …, 2017 - atsjournals.org
Rationale: Changes in the respiratory microbiome are associated with disease progression
in idiopathic pulmonary fibrosis (IPF). The role of the host response to the respiratory …
in idiopathic pulmonary fibrosis (IPF). The role of the host response to the respiratory …
An official American Thoracic Society Workshop report: obesity and asthma
Rationale: The developed world is currently facing an epidemic of obesity. With the
increased prevalence of obesity has come the recognition that obesity is a risk factor for …
increased prevalence of obesity has come the recognition that obesity is a risk factor for …
Systems vaccinology
Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …
The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection
The biomarker glycoprotein acetylation (GlycA) has been shown to predict risk of
cardiovascular disease and all-cause mortality. Here, we characterize biological processes …
cardiovascular disease and all-cause mortality. Here, we characterize biological processes …
Application of weighted gene co-expression network analysis for data from paired design
Investigating how genes jointly affect complex human diseases is important, yet challenging.
The network approach (eg, weighted gene co-expression network analysis (WGCNA)) is a …
The network approach (eg, weighted gene co-expression network analysis (WGCNA)) is a …