Germline determinants of gene expression in tumors are infrequently studied due to the
complexity of transcript regulation caused by somatically acquired alterations. We performed …

The majority of the heritability of coronary artery disease (CAD) remains unexplained,
despite recent successes of genome-wide association studies (GWAS) in identifying novel …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome …

To understand pathways mediating the inflammatory responses of human aortic endothelial
cells to oxidized phospholipids, we previously used a combination of genetics and genomics …

Genetic and genomic studies have advanced our knowledge of inherited Parkinson's
disease (PD), however, the etiology and pathophysiology of idiopathic PD remain unclear …

Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and
metabolic processes. Despite rapid progress in the understanding of these enzymes, a …

Background The predominant model for regulation of gene expression through DNA
methylation is an inverse association in which increased methylation results in decreased …

One of the challenges raised by next generation sequencing (NGS) is the identification of
clinically relevant mutations among all the genetic variation found in an individual. Network …

Despite a lack of consistent diagnostic criteria, the metabolic syndrome (MetS) is
increasingly evident in children and adolescents, portending a tsunami of chronic disease …

Interactions between cancer cells and cancer‐associated fibroblasts (CAFs) play an
important role in tumour development and progression. In this study we investigated the …