Background Patients with type 2 diabetes mellitus (T2D) have an increased risk of
cardiovascular disease and mortality compared to the background population …

Objective To assess the effect of targeting intensive glycaemic control versus conventional
glycaemic control on all cause mortality and cardiovascular mortality, non-fatal myocardial …

Background The global burden of type 2 diabetes mellitus (T2DM), together with the
presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent …

Obesity is associated with an increased risk of developing atherosclerosis, which may be
mediated, at least in part, by increased secretion of proinflammatory cytokines by adipose …

A large body of evidence supports that the dietary intake of polyphenols-particularly of
flavonoids and the specific class of flavonoids named flavanols-might be able to exert some …

Metabolic alterations such as insulin resistance are thought to underlie the endothelial
dysfunction and low grade inflammation found in morbid obesity. Twenty-six morbidly obese …

Endothelial dysfunction reflects an imbalance of vasodilators and vasoconstrictors.
Endogenous endothelin activity seems to be increased in human obesity and type 2 …

Background Endothelial dysfunction and inflammation are present in both type 2 diabetes
mellitus (T2DM) and obesity. In this paper we compared the role of weight loss and of …

Aims/hypothesis Inflammation plays a pathogenic role in the development of accelerated
atherosclerosis in diabetes. Soluble CD40 ligand (sCD40L) is enhanced in diabetes; …

We compared the levels of microparticles, platelet activation markers, soluble cell adhesion
molecules, and soluble selectins between hypertensive patients with and without type 2 …