Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

The discovery of robust antidepressant effects of ketamine in refractory patients has led to
increasing focus on agents targeting glutamatergic signaling as potential novel …

Objective To enhance the quality of care and clinical outcomes for children and adolescents
with major depressive disorder (MDD) and persistent depressive disorder (PDD). The aims …

Major depressive disorder (MDD) presents different clinical features in women and men,
with women being more affected and responding differently to antidepressant treatment …

Early‐life experience influences social and emotional behaviour in adulthood. Affiliative
tactile stimuli in early life facilitate the development of social and emotional behaviour …

Animal models of psychiatric disorders have been highly effective in advancing the field,
identifying circuits related to pathophysiology, and identifying novel therapeutic targets. In …

The development of molecular biomarkers for disease makes it possible for preventative
medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical …

Stress-related neuropathologies are pivotal in developing major depressive disorder (MDD)
and are often governed by gene-regulatory changes. Being a stress-responsive gene …

Background: Stressful events increase the risk for treatment-resistant depression (TRD), and
trauma-focused psychotherapy can be useful for TRD patients exposed to early life stress …

Abstract Background The FKBP5 and NR3C1 genes play an important role in stress
response, thus impacting mental health. Stress factor exposure in early life, such as …