Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Defining the role of natural killer cells in COVID-19
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences
MI Cheng, JH Li, L Riggan, B Chen, RY Tafti… - Nature …, 2023 - nature.com
Viral infection outcomes are sex biased, with males generally more susceptible than
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …
A guide to systems-level immunomics
The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …
Cellular and molecular biomarkers of long COVID: a scoping review
Summary Background Long-COVID (LC) encompasses diverse symptoms lasting months
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications
C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
KI Masood, M Yameen, J Ashraf, S Shahid… - Scientific reports, 2021 - nature.com
Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …