Contemporary synthetic strategies in organofluorine chemistry

R Britton, V Gouverneur, JH Lin, M Meanwell… - Nature Reviews …, 2021 - nature.com
Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …

Strategies for Nucleophilic C(sp3)–(Radio)Fluorination

INM Leibler, SS Gandhi, MA Tekle-Smith… - Journal of the …, 2023 - ACS Publications
This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

Fluorinated Perylene‐Diimides: Cathode Interlayers Facilitating Carrier Collection for High‐Performance Organic Solar Cells

J Yao, S Ding, R Zhang, Y Bai, Q Zhou… - Advanced …, 2022 - Wiley Online Library
Organic solar cells (OSCs) have experienced rapid progress with the innovation of near‐
infrared (NIR)‐absorbing small‐molecular acceptors (SMAs), while the unique electronic …

Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3, and CF3 Reactivity

H Jia, AP Häring, F Berger, L Zhang… - Journal of the American …, 2021 - ACS Publications
Here we report the synthesis and application of trifluoromethyl thianthrenium triflate (TT-
CF3+ OTf–) as a novel trifluoromethylating reagent, which is conveniently accessible in a …

Synthetic Advantages of Defluorinative C− F Bond Functionalization

LV Hooker, JS Bandar - Angewandte Chemie, 2023 - Wiley Online Library
Much progress has been made in the development of methods to both create compounds
that contain C− F bonds and to functionalize C− F bonds. As such, C− F bonds are becoming …

Visible-light-induced decarboxylative fluorination of aliphatic carboxylic acids catalyzed by iron

Y Zhang, J Qian, M Wang, Y Huang, P Hu - Organic Letters, 2022 - ACS Publications
An efficient and inexpensive protocol for the direct decarboxylative fluorination of aliphatic
carboxylic acids catalyzed with iron salts under visible light is presented. This new method …

Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs

G Chandra, DV Singh, GK Mahato, S Patel - Chemical Papers, 2023 - Springer
During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …

Wonderful fusion of organofluorine chemistry and decarboxylation strategy

P Xiao, X Pannecoucke, JP Bouillon… - Chemical Society …, 2021 - pubs.rsc.org
Decarboxylation strategy has been emerging as a powerful tool for the synthesis of fluorine-
containing organic compounds that play important roles in various fields such as …

Controllable Single and Double Difluoromethylene Insertions into C–Cu Bonds: Copper-Mediated Tetrafluoroethylation and Hexafluoropropylation of Aryl Iodides with TMSCF2 …

X Wang, S Pan, Q Luo, Q Wang, C Ni… - Journal of the American …, 2022 - ACS Publications
The selective difluoromethylene insertion into a C–Cu bond is a challenging task and is
currently limited to either a single CF2 insertion into CuCF3 or double CF2 insertions into …

Reactivities of electrophilic N–F fluorinating reagents

N Rozatian, DRW Hodgson - Chemical Communications, 2021 - pubs.rsc.org
Electrophilic fluorination represents one of the most direct and useful methods available for
the selective introduction of fluorine into organic compounds. Electrophilic fluorinating …