Progress in treating ischemic stroke (IS) and its delayed consequences has been
frustratingly slow due to the insufficient knowledge on the mechanism. One important factor …

Stroke is a leading cause of death and disability worldwide. Stroke prevention, early
diagnosis, and efficient acute treatment are priorities to successfully impact stroke death and …

Two classical surgical approaches for intraluminal filament middle cerebral artery occlusion
(MCAO), the Longa et al.(LM) and Koizumi et al. methods (KM), are used as alternatives in …

Adequate maternal dietary levels of one-carbon metabolites, such as folic acid and choline,
play an important role in the closure of the neural tube in utero; however, the impact of …

Recently, we have shown the differences in the early response of corticosterone and
inflammatory cytokines in the hippocampus and frontal cortex (FC) of rats with middle …

A vitamin B12 deficiency (vit. B12 def.) is common in the elderly, because of changes in
metabolism. Clinical studies have reported that a vit. B12 def. results in worse outcome after …

Background: Astragaloside IV (ASIV) is the primary pharmacologically active compound
found in Astragalus propinquus Schischkin, which has potential protective effects on cardiac …

Pterostilbene is a promising molecule with superior pharmacological activities and
pharmacokinetic characteristics compared to its structural analogue resveratrol, which could …

Nutrition is a modifiable risk factor for ischemic stroke. As people age their ability to absorb
some nutrients decreases, a primary example is vitamin B12. Older individuals with a …

The global population is aging and the prevalence of age-related diseases, such as stroke,
is predicted to increase. A vitamin B12 deficiency (vit. B12 def.) is common in the elderly …