Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Stopping pandemics before they start: Lessons learned from SARS-CoV-2

AM Edwards, RS Baric, EO Saphire, JB Ulmer - Science, 2022 - science.org
The vaccine and drug discovery responses to COVID-19 have worked far better than could
have been imagined. Yet by the end of 2021, more than 5 million people had died, and the …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C Xie, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

Development of therapeutic antibodies for the treatment of diseases

Z Wang, G Wang, H Lu, H Li, M Tang, A Tong - Molecular biomedicine, 2022 - Springer
Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in
1986, 165 antibody drugs have been approved or are under regulatory review worldwide …

Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR-and ACE2-positive …

J Shimizu, T Sasaki, R Koketsu, R Morita… - Scientific reports, 2022 - nature.com
Many therapeutic antibodies (Abs) and mRNA vaccines, both targeting SARS-CoV-2 spike
protein (S-protein), have been developed and approved in order to combat the ongoing …

Therapeutic antibodies in medicine

P Sharma, RV Joshi, R Pritchard, K Xu, MA Eicher - Molecules, 2023 - mdpi.com
Antibody engineering has developed into a wide-reaching field, impacting a multitude of
industries, most notably healthcare and diagnostics. The seminal work on developing the …

SARS-CoV-2: recent variants and clinical efficacy of antibody-based therapy

DD Singh, A Sharma, HJ Lee… - Frontiers in cellular and …, 2022 - frontiersin.org
Multiple variants of SARS-CoV-2 have emerged and are now prevalent at the global level.
Currently designated variants of concern (VOCs) are B. 1.1. 7, B1. 351, P. 1, B. 1.617. 2 …

A database of anti-coronavirus peptides

Q Zhang, X Chen, B Li, C Lu, S Yang, J Long, H Chen… - Scientific data, 2022 - nature.com
Since 2019, the novel coronavirus (SARS-COV-2) disease (COVID-19) has caused a
worldwide epidemic. Anti-coronavirus peptides (ACovPs), a type of antimicrobial peptides …

Potent antibodies against immune invasive SARS-CoV-2 Omicron subvariants

L Wang, Y Wang, H Zhou - International Journal of Biological …, 2023 - Elsevier
The development of neutralizing antibodies (nAbs) is an important strategy to tackle the
Omicron variant. Omicron N-terminal domain (NTD) mutations including A67V, G142D, and …

De novo design of anti-COVID drugs using machine learning-based equivariant diffusion model targeting the spike protein

V Niranjan, A Uttarkar, A Ramakrishnan… - Current Issues in …, 2023 - mdpi.com
The drug discovery and research for an anti-COVID-19 drug has been ongoing despite
repurposed drugs in the market. Over time, these drugs were discontinued due to side …