IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome

A Trautmann, O Boyer, E Hodson, A Bagga… - Pediatric …, 2023 - Springer
Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting
from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive …

Childhood nephrotic syndrome

M Vivarelli, K Gibson, A Sinha, O Boyer - The Lancet, 2023 - thelancet.com
Idiopathic nephrotic syndrome is the most common glomerular disease in children.
Corticosteroids are the cornerstone of its treatment, and steroid response is the main …

The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome

TA Al-Aubodah, L Aoudjit, G Pascale… - Nature …, 2023 - nature.com
The efficacy of the B cell-targeting drug rituximab (RTX) in childhood idiopathic nephrotic
syndrome (INS) suggests that B cells may be implicated in disease pathogenesis. However …

KDOQI US commentary on the 2021 KDIGO clinical practice guideline for the management of glomerular diseases

LH Beck Jr, I Ayoub, D Caster, MJ Choi, J Cobb… - American Journal of …, 2023 - Elsevier
The KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases
represents the first update to this set of recommendations since the initial set of KDIGO …

Clinical practice guidelines for nephrotic syndrome: consensus is emerging

A Sinha, A Bagga - Pediatric Nephrology, 2022 - Springer
Nephrotic syndrome is one of the most common chronic kidney diseases (CKD) in children
with an estimated incidence of 2.92 (range 1.15–16.9) per 100,000 children per year [1]. The …

An open label non-inferiority randomized controlled trial evaluated alternate day prednisolone given daily during infections vs. levamisole in frequently relapsing …

A Sinha, KG Devi, S Kalra, K Mani, P Hari, A Bagga - Kidney International, 2024 - Elsevier
Initial therapies for children with frequently relapsing nephrotic syndrome include alternate-
day prednisolone that is given daily during infections, or levamisole. In this open label, non …

Daily low-dose prednisolone to prevent relapse of steroid-sensitive nephrotic syndrome in children with an upper respiratory tract infection: PREDNOS2 RCT

MT Christian, NJA Webb, RL Woolley… - Health Technology …, 2022 - discovery.ucl.ac.uk
BACKGROUND: Most children with steroid-sensitive nephrotic syndrome have relapses that
are triggered by upper respiratory tract infections. Four small trials, mostly in children already …

Single-versus Divided-Dose Prednisolone for the First Episode of Nephrotic Syndrome in Children: An Open-Label RCT

T Khan, S Akhtar, D Mukherjee, S Basu… - Clinical Journal of the …, 2023 - journals.lww.com
Background Early morning single-dose prednisolone has a hypothetical advantage of less
hypothalamic-pituitary-adrenal (HPA) axis suppression, but lack of robust evidence has …

Patterns, triggers, and predictors of relapses among children with steroid-sensitive idiopathic nephrotic syndrome at the University of Abuja Teaching Hospital …

AE Ademola, I Ibraheem - Journal of The Egyptian Society of …, 2022 - journals.lww.com
Patterns, triggers, and predictors of relapses among childre... : Journal of The Egyptian Society of
Nephrology and Transplantation Patterns, triggers, and predictors of relapses among children …

Pulmonary surfactants and the respiratory-renal connection in steroid-sensitive nephrotic syndrome of childhood

G Cara-Fuentes, A Andres-Hernando, C Bauer… - Iscience, 2022 - cell.com
Steroid-sensitive nephrotic syndrome (SSNS) in childhood is usually due to minimal change
disease (MCD). Unlike many glomerular conditions, SSNS/MCD is commonly precipitated …