Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white
adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and …

An updated review of the existing knowledge regarding uremic toxins facilitates the design
of experimental studies. We performed a literature search and found 621 articles about …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …

Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but
detectable expression of adiponectin can be observed in cell types beyond adipocytes …

Results Median GFR was 66.5 (interquartile range, 40.0–88.3) ml/min per 1.73 m 2. Median
sclerostin level was 53.5 (interquartile range, 37.5–77.2) pmol/L, was higher in patients with …

The prevalence of obesity (body mass index [BMI] 30 kg/m2) has risen to epidemic
proportions and continues to be a major health problem worldwide. 1–3 The high …

Ectopic lipid accumulation is now known to be a mechanism that contributes to organ injury
in the context of metabolic diseases. In muscle and liver, accumulation of lipids impairs …

Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a
high rate into circulation. The ease with which the levels of adiponectin can be measured …

Objective—Obesity is recognized increasingly as a major risk factor for kidney disease. We
reported previously that plasma adiponectin levels were decreased in obesity, and that …

Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and
end-stage renal disease (ESRD) is a serious medical condition associated with increased …