Background Childhood maltreatment is a potent predictor of poor mental health across the
life span. We argue that there is a need to improve the understanding of the mechanisms …

Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Importance Exposure to bullying is associated with poor mental health. However, the degree
to which observed associations reflect direct detrimental contributions of exposure to …

Recent conceptualisations of resilience have advanced the notion that it is a dynamic and
multifaceted construct. However, its adaptive components, especially those forged by …

During the twentieth century, genes were considered the controlling force of life processes,
and the transfer of DNA the definitive explanation for biological heredity. Such views shaped …

Background DNA methylation (DNAm) is a potential mechanism for propagating the effects
of environmental exposures on child and adolescent mental health. In recent years, this field …

A systematic review following PRISMA guidelines was conducted to answer the question:
What epigenetic, telomeric and associated biological changes are associated with exposure …

DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …