Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
[HTML][HTML] Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
The mechanistic understanding of nascent RNAs in transcriptional control remains limited.
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …
Genome-wide analysis of human long noncoding RNAs: a provocative review
CP Ponting, W Haerty - Annual review of genomics and human …, 2022 - annualreviews.org
Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …
address how lncRNA loci and their transcripts, structures, interactions, and functions …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
De novo genes with an lncRNA origin encode unique human brain developmental functionality
NA An, J Zhang, F Mo, X Luan, L Tian… - Nature ecology & …, 2023 - nature.com
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and
are evolutionarily significant in general, yet how and why this all-or-nothing transition to …
are evolutionarily significant in general, yet how and why this all-or-nothing transition to …
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
M Aznaourova, N Schmerer, H Janga… - Proceedings of the …, 2022 - National Acad Sciences
The systemic immune response to viral infection is shaped by master transcription factors,
such as NF-κB, STAT1, or PU. 1. Although long noncoding RNAs (lncRNAs) have been …
such as NF-κB, STAT1, or PU. 1. Although long noncoding RNAs (lncRNAs) have been …
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
The genetic mechanisms underlying the expansion in size and complexity of the human
brain remain poorly understood. Long interspersed nuclear element–1 (L1) …
brain remain poorly understood. Long interspersed nuclear element–1 (L1) …