One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is
also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

Xist RNA expression, methylation of CpG islands, and hypoacetylation of histone H4 are
distinguishing features of inactive X chromatin. Here, we show that these silencing …

Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms
for regulation of gene expression during brain development and in memory formation …

▪ Abstract Fragile X syndrome is one of the most common forms of inherited mental
retardation. In most cases the disease is caused by the methylation-induced transcriptional …

Although protein phosphorylation has been characterized more extensively, modulation of
the acetylation state of signaling molecules is now being recognized as a key means of …