Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Recent advances in sequencing technologies provide unprecedented opportunities for
epigenetic biomarker development. Particularly the DNA methylation pattern—which is …

DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …

Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …

DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of
hematological malignancies. Manufacturing of these cellular products includes culture …

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm)
changes. We have identified CG dinucleotides (CpGs) that become continuously hyper-or …

Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …

Background DNA methylation-based biological age (DNAm age) is an important biomarker
for adult health. Studies in specific age ranges have found widely varying results about its …