Injury minimization after myocardial infarction: focus on extracellular vesicles

L Barile, E Marbán - European Heart Journal, 2024 - academic.oup.com
Despite improvements in clinical outcomes following acute myocardial infarction, mortality
remains high, especially in patients with severely reduced left ventricular ejection fraction …

Role of brain-derived neurotrophic factor in anxiety or depression after percutaneous coronary intervention

B Ning, T Ge, Y Wu, Y Wang, M Zhao - Molecular Neurobiology, 2024 - Springer
Anxiety or depression after percutaneous coronary intervention (PCI) is one of the key
clinical problems in cardiology that need to be solved urgently. Brain-derived neurotrophic …

Randomized evaluation of 5-month Ticagrelor monotherapy after 1-month dual-antiplatelet therapy in patients with acute coronary syndrome treated with drug-coated …

C Gao, B Zhu, J Liu, Z Jiang, T Hu, Q Wang… - BMC Cardiovascular …, 2024 - Springer
Background Patients treated with drug-coated balloons (DCB) have the theoretical
advantage of adopting a low-intensity antiplatelet regimen due to the absence of struts and …

Ethnic differences in thrombotic profiles of acute coronary syndrome patients and relationship to cardiovascular outcomes: a comparison of East Asian and White …

JW Suh, V Memtsas, YX Gue, HW Cho… - Thrombosis and …, 2024 - thieme-connect.com
Background East Asians (EAs), compared to white Caucasians (W), have a lower risk of
ischemic heart disease and a higher risk of bleeding with antithrombotic medications. The …

Antiplatelet therapy after PCI: the art and science of de-escalation

RF Storey - Circulation, 2024 - Am Heart Assoc
The principal goals of dual antiplatelet therapy (DAPT) after percutaneous coronary
intervention (PCI) are prevention of stent thrombosis and, in those treated for acute coronary …

Inflammation and platelet reactivity during adjunctive colchicine versus aspirin in patients with acute coronary syndrome treated with potent P2Y12 inhibitor

SY Lee, JY Cho, D Gorog, D Angiolillo, KH Yun… - Frontiers in …, 2024 - frontiersin.org
Background: In patients undergoing percutaneous coronary intervention (PCI), the use of
anti-inflammatory therapy with colchicine is associated with a reduction of recurrent ischemic …

[HTML][HTML] Impact of very low dose rivaroxaban in addition to dual antiplatelet therapy on endogenous fibrinolysis in acute coronary syndrome: The VaLiDate-R study

YX Gue, V Memtsas, R Kanji, DM Wellsted, A Busby… - Thrombosis …, 2024 - Elsevier
Background Impaired endogenous fibrinolysis is adverse cardiovascular risk factor in acute
coronary syndrome (ACS) patients. Addition of very low dose rivaroxaban (VLDR) to dual …

Antiplatelet therapy guided by CYP2C19 point-of-care pharmacogenetics plus multidimensional treatment decisions

V Voicu, N Diehm, I Moarof, S Parejo… - …, 2024 - Taylor & Francis
Aim: Implementation of CYP2C19 point-of-care (POC) pharmacogenetic (PGx) testing with
personalized treatment recommendations. Methods: POC CYP2C19 genotyping plus expert …

Antithrombotic management during percutaneous mechanical circulatory support–defining the status quo, before agreeing quo vadis

DA Gorog, A Combes - European Heart Journal: Acute …, 2024 - academic.oup.com
The incidence of cardiogenic shock (CS) is increasing 1–3 and continues to carry a very
high in-hospital mortality rate of 40–50%. 4, 5 Patients often present late and manifest …

De-escalation versus shortening of dual antiplatelet therapy

M Galli, F Costa, EP Navarese - 2024 - academic.oup.com
Despite a relentless effort to shift the paradigm in antiplatelet strategies towards a reduction
of bleeding without any trade-off in thrombotic events—known as bleeding reduction …